A novel gene, DPP10, encodes a homolog of dipeptidyl peptidases (DPPs) that cleave terminal dipeptides from cytokines and chemokines, and it presents a potential new target for asthma therapy. The DPP10 protein shares features with members of the S9B family of DPP serine proteases, which includes DPP4, a widely expressed enzyme that plays a central role in chemokine processing as part of the innate immune system. The locus displays a complex pattern of transcript splicing, with eight alternate first axons; four of which localize within the LD block strongly associated with asthma.
6430601K09Rik Dipeptidyl peptidase IV-related protein 3 Dipeptidyl peptidase X Dipeptidyl peptidase-like protein 2 DPL2 DPP X DPP10 DPPY DPRP3 DPRP-3 HGNC:20823 Inactive dipeptidyl peptidase 10 KIAA1492 Kv4 potassium channel auxiliary subunit OTTHUMP00000203618; dipeptidyl peptidase 10; Dipeptidyl peptidase IV-related protein 3; Dipeptidyl peptidase X; Dipeptidyl peptidase-like protein 2; dipeptidyl-peptidase 10 (inactive); dipeptidyl-peptidase 10 (non-functional); DPL2; DPP X; DPRP-3; Inactive dipeptidyl peptidase 10
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