Progerin is a 614 amino acid protein involved in Hutchinson-Gilford progeria syndrome. Progerin is most often generated by a point mutation (C1824T) in the LMNA gene that codes for lamin-A/C. This mutation activates a cryptic splice site and gives rise to a form of lamin A with a 50-amino acid internal deletion within the C-terminal domain of the protein. Approximately 80% of Hutchinson-Gilford progeria syndrome cases carry a single copy of the most common mutation, a silent point mutation, G608G (GGC > GGT), within exon 11 of the LMNA gene.
70 kDa lamin; lamin A/C-like 1; Lamin-A/C; Prelamin-A/C; Prelamin-A/C 70 kDa lamin LMN1 LMNA Renal carcinoma antigen NY-REN-32 Mutant lamin A/C progerin mutant Lamin AC Lamin A/C; Renal carcinoma antigen NY-REN-32
Cat # 15374341
100 µL
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