Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal domit retinitis pigmentosa.
220 kDa U5 snRNP-specific protein; apoptosis-regulated protein 1; apoptosis-regulated protein 2; p220; Pre-mRNA-processing-splicing factor 8; precursor mRNA processing protein; PRP8 homolog; PRP8 pre-mRNA processing factor 8 homolog; PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) HPRP8 PRP8 PRPC8 RP13; Splicing factor Prp8; U5 snRNP-specific protein; U5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8p
Cat # 15595052
100 µL
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100 µL
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100 µL
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100 µL
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100 µL
Cat # 13482837
100 µL
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