CAS RN 313254-51-2
IUPAC Namn:
2,2-diphenyl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}acetamide
Synonymer:
2,2-diphenyl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}acetamide
Molekylvikt (g/mol):
449.54
Molekylär sammansättning:
C23H19N3O3S2
InChi Key:
URSQNPPONHUJDL-UHFFFAOYSA-N
SMILES:
O=C(NC1=CC=C(C=C1)S(=O)(=O)NC1=NC=CS1)C(C1=CC=CC=C1)C1=CC=CC=C1
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2
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Resultat
1
Tocris Bioscience™ ICA 121431
CAS: 313254-51-2 Molekylformel: C23H19N3O3S2
2
ICA-121431, MedChemExpress
MedChemExpress ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 μM).
