CAS RN 702675-74-9
CAS RN 702675-74-9
IUPAC Namn:
N-(3-{[5-iodo-4-({3-[(thiophen-2-yl)formamido]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide
Synonymer:
N-{3-[(5-iodo-4-{[3-(thiophen-2-ylformamido)propyl]amino}pyrimidin-2-yl)amino]phenyl}pyrrolidine-1-carboxamide
Molekylvikt (g/mol):
591.47
Molekylär sammansättning:
C23H26IN7O2S
InChi Key:
VAVXGGRQQJZYBL-UHFFFAOYSA-N
SMILES:
IC1=CN=C(NC2=CC(NC(=O)N3CCCC3)=CC=C2)N=C1NCCCNC(=O)C1=CC=CS1
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Resultat
1
Tocris Bioscience™ BX 795
CAS: 702675-74-9 Molekylformel: C23H26IN7O2S
2
BX795, MedChemExpress
MedChemExpress BX795 is a potent and selective inhibitor of PDK1, with an IC50 of 6 nM. BX795 is also a potent and relatively specific inhibitor of TBK1 and IKKɛ, with an IC50 of 6 and 41 nM, respectively. BX795 blocks phosphorylation of S6K1, Akt, PKCδ, and GSK3β, and has lower selectivity over PKA, PKC, c-Kit, GSK3β etc. BX795 modulates autophagy.
