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1,1-Dimethylbiguanide hydrochloride

Produktkod. 15495609
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Produktkod. 15495609 Leverantör Thermo Scientific Alfa Aesar Leverantörsnummer J63361.14
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Beskrivning

An antidiabetic agent | CAS: 1115-70-4 | C4H12ClN5 | 165.63 g/mol

1,1-Dimethylbiguanide hydrochloride is used as an antidiabetic agent, used in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2. It may also reduce weight gain in people taking atypical antipsychotics, used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• 1,1-Dimethylbiguanide consists of two guanidines with methyl substitutions at position 1

• 1,1-Dimethylbiguanide hydrochloride inhibits complex I of the mitochondrial respiratory chain, increasing AMP and activating target genes

• 1,1-Dimethylbiguanide hydrochloride enhances insulin sensitivity and fatty acid oxidation in cells

• 1,1-Dimethylbiguanide hydrochloride may also have antineoplastic action through the mammalian target of rapamycin pathway

• It is suitable for the laboratory research of diabetes, obesity, and related metabolic disorders

• It is also useful for the laboratory study of mammalian target of rapamycin (mTOR) pathways and AMPK ratios within the cell

TRUSTED_SUSTAINABILITY

Kemiska identifierare

CAS 1115-70-4
Molekylformel C4H12ClN5
Molekylvikt (g/mol) 165.63
MDL-nummer MFCD00012582
InChI-nyckel OETHQSJEHLVLGH-UHFFFAOYSA-N
Synonym metformin hydrochloride, 1,1-dimethylbiguanide hydrochloride, metformin hcl, glucophage, riomet, diabefagos, meguan, metformin monohydrochloride, benofomin, denkaform
PubChem CID 14219
IUPAC-namn hydrogen 1-[(diaminomethylidene)amino]-N,N-dimethylmethanimidamide chloride
LEDER [H+].[Cl-].CN(C)C(=N)N=C(N)N

Specifikationer

Kemiskt namn eller material 1,1-Dimethylbiguanide hydrochloride
Smältpunkt 218°C to 226°C
Färg White
Linjär formel NH2C(=NH)NHC(=NH)N(CH3)2·HCl
Kvantitet 25 g
Merck Index 14,5938
Löslighetsinformation Soluble in water (50mg/ml),ethanol,and DMSO (50 mM).
Formel vikt 165.62
Fysisk form Powder

RUO – Research Use Only

Produkttitel
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