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CD301b (MGL2) Rat anti-Mouse, Clone: 11A10-B7, eBioscience™

Produktkod. 15587436
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Kvantitet:
25 μg
Förpackningsstorlek:
25µg
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15587436 25 μg 25µg
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Produktkod. 15587436 Leverantör Invitrogen Leverantörsnummer 14301180

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Beskrivning

Rat Monoclonal Antibody

Description: The monoclonal antibody 11A10-B7 recognizes mouse CD301b. CD301b is also known as macrophage galactose-type C-type lectin 2 (MGL2). CD301b expression is restricted to dermal dendritic cells, connection tissue, and bone marrow derived dendritic cells. Macrophages also express CD301b at low levels. CD301b contains a single carbohydrate recognition domain that recognizes protein antigens that have a galactose and N-acetylgalactosamine (Gal/GalNAc). Gal/GalNAc protein antigens are efficiently internalized through CD301b and presented to antigen specific CD4+ cells via MHC Class II. CD301b+ dendritic cells are believed to play an important role in TH2 priming. Applications Reported: This 11A10-B7 antibody has been reported for use in immunohistochemical staining of frozen tissue sections, and microscopy. Applications Tested: This 11A10-B7 antibody has been tested by immunohistochemistry of frozen mouse tissue and can be used at less than or equal to 10 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

CD301b is also known as macrophage galactose-type C-type lectin 2 (MGL2). CD301b expression is restricted to dermal dendritic cells, connection tissue, and bone marrow derived dendritic cells. Macrophages also express CD301b at low levels. CD301b contains a single carbohydrate recognition domain that recognizes protein antigens that have a galactose and N-acetylgalactosamine (Gal/GalNAc). Gal/GalNAc protein antigens are efficiently internalized through CD301b and presented to antigen specific CD4+ cells via MHC Class II. CD301b+ dendritic cells are believed to play an important role in TH2 priming.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen CD301b (MGL2)
Användningsområden Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen)
Klassificering Monoclonal
Klona 11A10-B7
Koncentration 0.5 mg/mL
Konjugera Unconjugated
Formulering PBS with 0.09% sodium azide; pH 7.2
Gen Mgl2
Gene Alias Macrophage galactose-type C-type lectins 2; MGL2; Macrophage galactose-type C-type lectin; CD301
Gensymboler Mgl2
Värd art Rat
Reningsmetod Affinity chromatography
Kvantitet 25 μg
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 216864
Målarter Mouse
Innehåll och lagring 4° C
Produkttyp Antibody
Form Liquid
Isotyp IgG2a λ
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For Research Use Only.

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