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CD274, NA/LE Mouse anti-Human, Unlabeled, Clone: MIH1, BD
Beskrivning
The MIH1 monoclonal antibody specifically binds to CD274, which is also known as, B7 homolog 1 (B7-H1), Programmed cell death 1 ligand 1 (PDCD1 ligand, PDCD1L1, PDCD1LG1), or Programmed death ligand 1 (PD-L1, PDL1). CD274 and PD-L2 (CD273) are type I transmembrane glycoproteins that belong to the B7 family and serve as ligands for CD279 (Program Death 1/PD-1). CD274 is expressed on antigen-presenting cells including activated monocytes/macrophages and dendritic cells, as well as, activated T cells, and keratinocytes. CD274 is also expressed on placental trophoblasts, myocardial endothelium, cortical thymic epithelial cells, and on most carcinomas. CD274 plays an important role in regulating T cell responses. The MIH1 antibody blocks CD279 binding to CD274 and can enhance the proliferation and cytokine production of activated T cells.
Specifikationer
Specifikationer
| Antigen | CD274, NA/LE |
| Klassificering | Monoclonal |
| Klona | MIH1 |
| Koncentration | 1.0mg/mL |
| Konjugera | Unconjugated |
| Formulering | No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay. |
| Gene Alias | B7-H1, B7-H, PD-L1, PDL1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1 |
| Värd art | Mouse |
| Immunogen | Human CD274 Transfected Cell Line |
| Reningsmetod | Affinity Purified |
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