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Tocris Bioscience™ 3-Deazaneplanocin A hydrochloride
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Produktkod. 30001570
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Kvantitet:
1 mg
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Produktkod. Kvantitet
30001570 1 mg
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Produktkod. 30001570 Leverantör Tocris Bioscience™ Leverantörsnummer 4703/1

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Beskrivning

EZH2 histone methyltransferase inhibitor

3-Deazaneplanocin A hydrochloride is a histone methyltransferase inhibitor; decreases global histone methylation. 3-Deazaneplanocin A hydrochloride inhibits EZH2 histone methyltransferase and s-adenosylhomocysteine (SAH) hydrolase activity. Blocks trimethylation of lysine 27 on histone H3 and lysine 20 on histone H4 in vitro. 3-Deazaneplanocin A hydrochloride induces apoptosis in multiple cancer cell lines and has no apoptotic effect on normal cells. Enhances Oct4 expression in chemically induced pluripotent stem cells (CiPSCs).

DZNep synthesized to Ancillary Material Grade also available.

For more information about how 3-Deazaneplanocin A hydrochloride may be used, see our protocol: Highly Efficient Generation of CiPSCs from MEFs

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Specifikationer

Kemiskt namn eller material 3-Deazaneplanocin A hydrochloride
CAS 120964-45-6
Kvantitet 1 mg
Molekylformel C12H15ClN4O3
Formel vikt 298.73
Renhet >98%
Molekylvikt (g/mol) 298.727
Produkttitel
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