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Invitrogen™ 4-1BB Ligand Recombinant Rabbit Monoclonal Antibody (014), APC

Produktkod. 17800656
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Kvantitet:
100 Tests
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Produktkod. Kvantitet
17800656 100 Tests
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Produktkod. 17800656 Leverantör Invitrogen™ Leverantörsnummer MA546776
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Beräknad leverans: 14-12-2026
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Beskrivning

Rabbit Recombinant Monoclonal Antibody

Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse 4-1BBL (CD137L) (Arg104-Glu309) and conjugated with APC under optimum conditions, the unreacted APC was removed. Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen 4-1BB Ligand
Användningsområden Flow Cytometry
Klassificering Recombinant Monoclonal
Klona 014
Koncentration 100 μg/mL
Konjugera APC
Formulering PBS with 0.5% BSA and 0.03% ProClin 300
Gen TNFSF9
Genaccessionsnr. P41274
Gene Alias 4 1 BB Ligand; 4 1 BBL; 41BB Ligand; 4-1BB ligand; 41BBL; 4-1BBL; 4-1BB-L; AI848817; CD 137 Ligand; CD 137L; CD137 Ligand; CD137L; Cd157l; CDw137L; costimulatory molecule; homolog of mouse 4-1BB-L; Ly63l; receptor 4-1BB ligand; TNFRSF9; Tnfsf9; TNLG5A; tumor necrosis factor (ligand) superfamily member 9; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand 5A; tumor necrosis factor ligand superfamily member 9; tumor necrosis factor superfamily member 9
Gensymboler TNFSF9
Värd art Rabbit
Immunogen Recombinant protein encoding Mouse 4-1BB Ligand (Arg104-Glu309).
Reningsmetod Protein A
Kvantitet 100 Tests
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 21950
Målarter Mouse
Innehåll och lagring 4°C, store in dark, DO NOT FREEZE!
Produkttyp Antibody
Form Liquid
Isotyp IgG
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