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  7. A 1070722, Tocris Bioscience™

A 1070722, Tocris Bioscience™

Catalog Number 18075922
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
1384424-80-9
C17H13F3N4O2
362.312
VQPBIJGXSXEOCU-UHFFFAOYSA-N
kinome_2278, kinome_2324, 1-7-methoxyquinolin-4-yl-3-6-trifluoromethyl pyridin-2-yl urea
49830684
1-(7-methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
COC1=CC2=NC=CC(=C2C=C1)NC(=O)NC3=CC=CC(=N3)C(F)(F)F
This item is not returnable. View return policy
1384424-80-9
C17H13F3N4O2
362.312
VQPBIJGXSXEOCU-UHFFFAOYSA-N
kinome_2278, kinome_2324, 1-7-methoxyquinolin-4-yl-3-6-trifluoromethyl pyridin-2-yl urea
49830684
1-(7-methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
COC1=CC2=NC=CC(=C2C=C1)NC(=O)NC3=CC=CC(=N3)C(F)(F)F

Description

Highly potent, selective GSK-3 inhibitor

Potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β). Displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau in vitro; protects rat primary cortical neurons against β amyloid and glutamate challenge. Brain penetrant.
Quantity 10 mg
Formula Weight 362.31
Percent Purity >99%
Chemical Name or Material A 1070722
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