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Tocris Bioscience™ A 83-01
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Produktkod. 18084932
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Produktkod. Kvantitet
18084932 10 mg
18025492 50 mg
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Produktkod. 18084932 Leverantör Tocris Bioscience™ Leverantörsnummer 2939/10

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Selective inhibitor of TGF-βRI, ALK4 and ALK7

A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). A 83-01 blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542 (Cat. No. 1614). A 83-01 inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs. Also promotes neural differentiation of hPSCs as part of a chemical cocktail.

For more information about how A 83-01 may be used, see our protocol: Converting Fibroblasts into Cardiomyocytes (9C Cocktail)

TRUSTED_SUSTAINABILITY

Kemiska identifierare

CAS 909910-43-6
Molekylformel C25H19N5S

Specifikationer

Kemiskt namn eller material A 83-01
Kvantitet 10 mg
Formel vikt 421.52
Renhet >98%
Molekylvikt (g/mol) 421.522
Produkttitel
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