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STEMCELL Technologies A769662

Produktkod. 17170142
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Kvantitet:
10 mg
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Produktkod. Kvantitet
17170142 10 mg
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Produktkod. 17170142 Leverantör STEMCELL Technologies Leverantörsnummer 72922

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Beskrivning

AMPK activator

  • A769662 is a cell-permeable, direct activator of AMP-activated protein kinase (AMPK) with an EC50 of 116 nM (Goransson et al.) A 4.1-fold stimulation of AMPK is observed, via an allosteric mechanism, which potentially inhibits dephosphorylation on Thr172 (Goransson et al.; Sanders et al.) A769662 specifically activates β1 subunit–containing AMPK heterotrimers, and its effects are independent of kinases upstream of AMPK
  • Activation of AMPK can inhibit the mTORC1 signaling pathway (Huang et al.) A769662 is also an inhibitor of Na(+)-K(+)-ATPase (Benziane et al.)
  • Inhibits reprogramming of mouse fibroblasts to induced pluripotent stem cells (Vazquez-Martin et al.)
  • Inhibits proliferation of mesenchymal stem cells (de Meester et al.)
  • Delays tumor onset in PTEN-deficient mice (Huang et al.)
  • Inhibits fatty acid synthesis in primary rat hepatocytes and lowers blood glucose in Sprague Dawley rats (Cool et al.)

Specifikationer

CAS 844499-71-4
Kvantitet 10 mg
Molekylformel C20H12N2O3S
Renhet ≥98%
Produkttitel
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