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Eurofins DiscoverX Abl Protein, Active
Beskrivning
The abl oncogene was initially identified as the viral transforming gene (v-abl) of Abelson murine leukemia virus (A-MuLV), from a chemically thymectomized mouse inoculated with Moloney murine leukemia virus (M-MuLV). The v-abl genome consists of M-MuLV gag sequences fused to mouse c-abl, resulting in the production of phosphoroteins, p160 and p120 gag/c-abl with protein-tyrosine kinase activity, as the major translational products. The abl oncogene is implicated in serval human leukemias including chronic myelocytic (CML), adult acute lymphoblastic (ALL) and pediatric ALL. In these leukemias the c-abl proto-oncogene undergoes a chromosomal translocation producing the Philadelphia (Ph¢) chromosome resulting in the fusion of c-abl sequences to the bcr gene of chromosome 22, and the molecular consequences of this translocation is the generation of a chimeric bcr/c-abl mRNA encoding activated abl protein-tyrosine kinase.
GenBank J02995. The recombinant protein contains four amino acids which conflict with J02995, these are L782P, G784R, W785L, and L786V, and are reported inGenBank XM_130089.
Specifikationer
Specifikationer
| Formulering | mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1 % 2-mercaptoethanol. Frozen solution. |
| Molekylvikt (g/mol) | 123.5 kDa |
| Kvantitet | 10 μg |
| Art | Mouse |
| Rekombinant | Recombinant |
| Protein Tag | N-terminal 6His |
| Uttryckssystem | Recombinant enzyme expressed in Sf21 insect cells |
| Proteinform | Truncated |
| Renhet eller kvalitetsklass | ≥34% |
| Protein | Abl (mouse), active |
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