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Tocris Bioscience™ ABT 263
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Produktkod. 18789916
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10 mg
50 mg
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Produktkod. Kvantitet
18789916 10 mg
18707746 50 mg
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Produktkod. 18789916 Leverantör Tocris Bioscience™ Leverantörsnummer 7680/10

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Beskrivning

High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor

ABT 263 is a high affinity inhibitor of Bcl-2 family proteins (Ki values are 0.5 nM, <1 nM and <1 nM in Bcl-xL, Bcl-2 and Bcl-W respectively). ABT 263 induces G1/G0 phase arrest, apoptosis and autophagy in cancer cells in vitro (IC50 = 3.4 - 12 μM). In vivo, ABT 263 displays a synergistic antitumor effect with rituximab and Bortezomib (Cat. No. 7282), Docetaxel (Cat. No. 4056) and Erlotinib (Cat. No. 7194), and inhibits growth of SCLC xenografts when combined with (+)-JQ1 (Cat. No. 4499). ABT 263 also reduces inflammation and viral-induced senescence in SARS-CoV-2 infection in vivo, and clears senescent cells and rejuvenates aging stem cells. Orally bioavailable.
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Specifikationer

Kemiskt namn eller material 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1 R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
CAS 923564-51-6
Kvantitet 10 mg
Mål Bcl-2 Family Inhibitors
Molekylformel C47H55ClF3N5O6S3
Renhet 0.98
Produkttitel
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