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ACE2 Mouse anti-Human, Clone: 2F12A4, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66699-1-IG-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16828825

  • 1236.20 SEK / 20µL
Estimated Shipment: 07-12-2021

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Description

Description

This antibody is specific to ACE2.

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
Specifications

Specifications

ACE2
2F12A4
Unconjugated
ACE2
Liquid
ACE2
ACE2 Fusion Protein Ag15554
Protein G
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q9BYF1
ACE related carboxypeptidase, ACE2, ACEH, DKFZp434A014, Metalloprotease MPROT15
Mouse
IgG1
20 μL
-20°C
Primary
59272
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