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ACVR1 (ALK2) [R206H] Recombinant Human Protein

ACVR1 (ALK2) [R206H] Recombinant Human Protein

Brand:  Invitrogen PV6233

Additional Details : Weight : 0.01000kg

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Product Code. 15468893

  • 10180.00 SEK / 100µg


Estimated Shipment date
from Supplier 07-11-2017
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Disclaimers:

For Research Use Only. Not for use in diagnostic procedures.


Description

Description

ACVR1 (ALK2) belongs to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins which encodes activin A type I receptor. ACVR1 signals a particular transcriptional response in concert with activin type II receptors. Mutations in ACVR1 are associated with fibrodysplasia ossificans progressiva (FOP) and the mutations are located in or adjacent to the GS regulatory region or active site of the kinase. The mutations in ACVR1 were predicted by protein structure homology modeling to activate the ACVR1 protein and enhance receptor signaling. Dysregulated ACVR1 kinase activity plays a role in the pathogenesis of FOP. Recombinant human ACVR1 (R206H) (147-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

  • Validated in LanthaScreen™ Kinase Binding Assay
  • Protocols available for simple use and optimized performance
  • Multiple pack sizes available for convenient use
  • Specifications

    Specifications

    NP_001096.1
    Pharma and biopharma, protein assays and analysis, target and lead identification and validation
    ACVR1 (ALK2) [R206H] Recombinant Human Protein
    >95% by SDS-PAGE
    –68 to –85°C
    1 Each
    ACVR1 (ALK2) [R206H] Recombinant Human Protein
    Kinase assay
    ACVR1 (ALK2) [R206H] Recombinant Human Protein
    Human
    0.1mg/mL
    67.6kDa
    7.5
    100μg
    For research use only. Not for use in diagnostic procedures
    ACVR1, FOP, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2
    ACVR1 (ALK2) R206H was pre-diluted in enzyme dilution buffer and assayed in 5mM MOPS (pH 7.2), 2.5mM β-glycerol-phosphate, 5mM MgC12, 0.4mM EDTA, 0.05mM DTT, with 50μM ATP, trace [33P]-γ-ATP and 200μg/mL casein protein substrate for 15 min.s at 30&d
    Amino acids 147-end
    6nmoles of phosphate transferred to Casein protein substrate per minute per mg of total protein at 30°C
    GST Tag