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AKAP3 Mouse anti-Human, Mouse, Clone: 3C11H9, Proteintech
Mouse Monoclonal Antibody
1656.73 SEK - 4721.67 SEK
Specifications
Antigen | AKAP3 |
---|---|
Clone | 3C11H9 |
Concentration | 1.76 mg/mL |
Applications | Immunohistochemistry (Paraffin), Western Blot |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
16827965
|
Proteintech
66255-1-IG-20UL |
20 μL |
1656.73 SEK
20µL |
Estimated Shipment: 23-04-2024 Log in to see stock. |
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16817965
|
Proteintech
66255-1-IG-150UL |
150 μL |
4721.67 SEK
150µL |
Estimated Shipment: 23-04-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
The type II cAMP-dependent protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins, designated A-kinase anchoring proteins (AKAP). AKAP 3, also known as AKAP 110, FSP95, PRKA3 and SOB1, binds both PKA and PDE4A and functions as a scaffolding protein in spermatozoa to regulate local cAMP concentrations and modulate sperm functions. Expression of AKAP 3 in normal tissues is restricted to the testis, where bicarbonate stimulates tyrosine phosphorylation of AKAP 3, thereby increasing its recruitment of PKA. AKAP-3 also exhibits high expression in patients with epithelial ovarian cancer (EOC). It demonstrates tumor-restricted expression and appears to be associated with worse overall survival, which make AKAP 3 a potential target for antigen-specific immunotherapy in EOC.Specifications
AKAP3 | |
1.76 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
A kinase anchor protein 3, AKAP 110, AKAP 3, AKAP110, AKAP3, Cancer/testis antigen 82, CT82, Fibrousheathin 1, Fibrousheathin I, FSP95, PRKA3, SOB1, Sperm oocyte binding protein | |
AKAP3 | |
IgG2a | |
Protein A | |
Antibody |
3C11H9 | |
Immunohistochemistry (Paraffin), Western Blot | |
Unconjugated | |
Mouse | |
Human, Mouse | |
O75969, O88987 | |
10566, 11642 | |
AKAP3 Fusion Protein Ag4885 | |
Primary | |
-20°C | |
AKAP3 |