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STEMCELL Technologies AKT Inhibitor VIII

Produktkod. 17110152
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1 mg
10 mg
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Produktkod. 17110152 Leverantör STEMCELL Technologies Leverantörsnummer 72942

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Beskrivning

PI3K/AKT pathway inhibitor; Inhibits AKT1, AKT2, and AKT3

  • AKT Inhibitor VIII is a cell-permeable, allosteric inhibitor of all three forms of the kinase AKT (AKT1, AKT2, and AKT3) with IC50 values of 58, 210, and 2,200 nM, respectively (Lindsley et al.; Calleja et al.) It displays good selectivity against a panel of 70 other kinases with micromolar inhibition against some kinases, such as calcium/calmodulin-dependent protein kinase 1 and smooth muscle myosin light-chain kinase (Logie et al.)
  • Sensitizes prostate tumor and cervical carcinoma cells to apoptotic stimuli (DeFeo-Jones et al.)
  • Blocks mitosis and inhibits migration of HeLa cells (Jo et al.)
  • Reduces insulin-dependent gene repression in liver cells leading to reduced insulin sensitivity (Logie et al.)

Specifikationer

CAS 612847-09-3
Synonym AKTi-1/2; AKT 1/2 inhibitor
Kvantitet 1 mg
Molekylformel C34H29N7O
Renhet ≥98%
Produkttitel
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