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Alpha E catenin Mouse anti-Human, Mouse, Clone: 2B7B8, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66221-1-IG-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16877895

  • 3313.85 SEK / 150µL
Estimated Shipment: 30-11-2021

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Description

Description

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
Specifications

Specifications

Alpha E catenin
2B7B8
Unconjugated
CTNNA1
Liquid
CTNNA1
Alpha E catenin Fusion Protein Ag23603
Protein G
RUO
Antibody
Monoclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
2.08 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P26231, P35221
Alpha E catenin, Cadherin associated protein, CAP102, Catenin alpha 1, CTNNA1
Mouse
IgG1
150 μL
-20°C
Primary
12385, 1495
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