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Tocris Bioscience™ AMG 853
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Produktkod. 30000887
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Kvantitet:
10 mg
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Produktkod. Kvantitet
30000887 10 mg
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Produktkod. 30000887 Leverantör Tocris Bioscience™ Leverantörsnummer 5701/10

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Beskrivning

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist (IC50 values are 8 and 35 nM, respectively in plasma). Inhibits PGD2-induced down modulation of CRTH2 on CD16- granulocytes in human whole blood as well as PGD2-induced cAMP response in platelets. Inhibits PGD2-induced airway constriction in vivo. Also inhibits BRD4 (Kd = 170 nM). Orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifikationer

Kemiskt namn eller material 5-Chloro-4-[2-[[(2-chloro-4-cyclopropylphenyl)sulfonyl]amino]-4-[[(1,1-dimethylethyl)amino]carbonyl]
CAS 1169483-24-2
Kvantitet 10 mg
Löslighet Soluble to 100mM in DMSO and to 100mM in ethanol
Molekylformel C28H27Cl2FN2O6S
Formel vikt 609.49
Renhet >98%
Molekylvikt (g/mol) 609.49
Produkttitel
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