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AMG 853, Tocris Bioscience™ Product Code.: 30000887
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AMG 853, Tocris Bioscience™

Product Code. 30000887
10 mg
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Quantity:
10 mg
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Product Code. 30000887

Brand: Tocris Bioscience 5701/10

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This item is not returnable. View return policy

Description

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist (IC50 values are 8 and 35 nM, respectively in plasma). Inhibits PGD2-induced down modulation of CRTH2 on CD16- granulocytes in human whole blood as well as PGD2-induced cAMP response in platelets. Inhibits PGD2-induced airway constriction in vivo. Also inhibits BRD4 (Kd = 170 nM). Orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

CAS 1169483-24-2
Molecular Formula C28H27Cl2FN2O6S
Linear Formula C28H27Cl2FN2O6S
Quantity 10 mg
Synonym vidupiprant, unii-61otz32xnc, 61otz32xnc, amg 853 amg853;vidupiprant, 2-4-4-tert-butylcarbamoyl-2-2-chloro-4-cyclopropylphenylsulfonamido phenoxy-5-chloro-2-fluorophenyl acetic acid, benzeneacetic acid, 5-chloro-4-2-2-chloro-4-cyclopropylphenyl sulfonyl amino-4-1,1-dimethylethyl amino carbonyl phenoxy-2-fluoro, vidupiprant usan:inn, 4-4-tert-butylcarbamoyl-2-2-chloro-4-cyclopropylbenzenesulfonamido phenoxy-5-chloro-2-fluorophenyl acetic acid, vidupiprant usan/inn, d0yb2y
Solubility Information Soluble to 100mM in DMSO and to 100mM in ethanol
InChI Key PFWVGKROPKKEDW-UHFFFAOYSA-N
SMILES CC(C)(C)NC(=O)C1=CC(=C(C=C1)OC2=C(C=C(C(=C2)F)CC(=O)O)Cl)NS(=O)(=O)C3=C(C=C(C=C3)C4CC4)Cl
IUPAC Name 2-[4-[4-(tert-butylcarbamoyl)-2-[(2-chloro-4-cyclopropylphenyl)sulfonylamino]phenoxy]-5-chloro-2-fluorophenyl]acetic acid
Molecular Weight (g/mol) 609.49
PubChem CID 42641863
Formula Weight 609.49
Chemical Name or Material 5-Chloro-4-[2-[[(2-chloro-4-cyclopropylphenyl)sulfonyl]amino]-4-[[(1,1-dimethylethyl)amino]carbonyl], Soluble to 100mM in DMSO and to 100mM in ethanol
Grade >98%
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