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Description
Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist (IC50 values are 8 and 35 nM, respectively in plasma). Inhibits PGD2-induced down modulation of CRTH2 on CD16- granulocytes in human whole blood as well as PGD2-induced cAMP response in platelets. Inhibits PGD2-induced airway constriction in vivo. Also inhibits BRD4 (Kd = 170 nM). Orally bioavailable.

Specifications
Specifications
CAS | 1169483-24-2 |
Molecular Formula | C28H27Cl2FN2O6S |
Linear Formula | C28H27Cl2FN2O6S |
Quantity | 10 mg |
Synonym | vidupiprant, unii-61otz32xnc, 61otz32xnc, amg 853 amg853;vidupiprant, 2-4-4-tert-butylcarbamoyl-2-2-chloro-4-cyclopropylphenylsulfonamido phenoxy-5-chloro-2-fluorophenyl acetic acid, benzeneacetic acid, 5-chloro-4-2-2-chloro-4-cyclopropylphenyl sulfonyl amino-4-1,1-dimethylethyl amino carbonyl phenoxy-2-fluoro, vidupiprant usan:inn, 4-4-tert-butylcarbamoyl-2-2-chloro-4-cyclopropylbenzenesulfonamido phenoxy-5-chloro-2-fluorophenyl acetic acid, vidupiprant usan/inn, d0yb2y |
Solubility Information | Soluble to 100mM in DMSO and to 100mM in ethanol |
InChI Key | PFWVGKROPKKEDW-UHFFFAOYSA-N |
SMILES | CC(C)(C)NC(=O)C1=CC(=C(C=C1)OC2=C(C=C(C(=C2)F)CC(=O)O)Cl)NS(=O)(=O)C3=C(C=C(C=C3)C4CC4)Cl |
IUPAC Name | 2-[4-[4-(tert-butylcarbamoyl)-2-[(2-chloro-4-cyclopropylphenyl)sulfonylamino]phenoxy]-5-chloro-2-fluorophenyl]acetic acid |
Molecular Weight (g/mol) | 609.49 |
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Product Title
AMG 853, Tocris Bioscience™ >
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