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Tocris Bioscience™ AMZ 30
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Produktkod. 18778606
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Produktkod. Kvantitet
18778606 10 mg
18728686 50 mg
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Produktkod. 18778606 Leverantör Tocris Bioscience™ Leverantörsnummer 6923/10

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Beskrivning

Potent, selective and irreversible protein phosphatase methylesterase-1 (PME-1) inhibitor

AMZ 30 is a potent, selective and irreversible inhibitor of protein phosphatase methylesterase-1 (PME-1; IC50 = 600 nM) with > 100-fold selectivity for PME-1 over other serine hydrolases in human cell lysates. AMZ 30 inactivates PME-1 and reduces the demethylated form of serine/threonine protein phosphatase 2A (PP2A) in HEK 293T cells. AMZ 30 perturbs leucine carboxyl methyltransferase-1 (LCMT1)-PME-1 methylation equilibrium leading to shortening of mitotic spindles and mitotic arrest in HeLa cells. It also shows antiproliferative properties in an in vitro model of endometrial carcinoma.
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Specifikationer

Kemiskt namn eller material (2 E)-2-[(4-Fluorophenyl)sulfonyl]-3-[1-[(3-nitrophenyl)sulfonyl]-1 H-pyrrol-2-yl]-2-propenenitrile
CAS 1313613-09-0
Kvantitet 10 mg
Mål Hydrolase Inhibitors
Molekylformel C19H12FN3O6S2
Renhet 0.98
Produkttitel
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