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anti-alpha Synuclein Clone: 14H2L1, Invitrogen™

alpha Synuclein Monoclonal antibody 701085 from Thermo Scientific™ Pierce™ specifically detects alpha Synuclein in Human samples, and it is validated for WB, IF and ICC

Brand:  Invitrogen 701085

Additional Details : Weight : 0.01000kg

Product Code. 15397024

  • 3030.00 SEK / 100µg


EU Stock 5
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Description

Description

Alpha-Synuclein belongs to the Synuclein family, which also includes beta and gamma Synuclein, and is predominantly expressed in neurons, concentrated at synaptic terminals. Synucleins may be involved in the regulation of dopamine release and transport and the modulation of synaptic vesicle function. Alpha-Synuclein is a small, presynaptic protein that is the major nonamyloid component of the pathological inclusions characteristic of a wide range of neurodegenerative disorders, collectively known as synucleinopathies. It is involved in the formation of SNARE complexes. Most significantly, aggregated Alpha-Synuclein is one of the major components found in the Lewy bodies that occur in Parkinson's disease (PD) and other neurodegenerative disorders. Mutation of the alpha-synuclein gene is associated with familial forms of PD. Alpha-Synuclein is known to reduce the fibrillization of the microtubule-associated protein, tau, to bind various targets such as 14-3-3, protein kinase C, synphilin-1, Elk and Tat-binding protein 1.

701085 detects alpha Synuclein in Human samples. 701085 has been successfully used in WB, IF and ICC procedures. The immunogen for 701085 is peptide corresponding to amino acids 117-125 of human synuclein, alpha.

Applications:

Immunocytochemistry, Immunofluorescence, Western Blotting

Specifications

Specifications

alpha Synuclein
Unconjugated
P37840
Rabbit
IgG
Store at 2 to 8°C for up to 1 month. For long term storage, store at -20°C.
Monoclonal
Human
14H2L1
100μg of Protein A antibody in PBS with 0.09% sodium azide;
Purified
Peptide corresponding to amino acids 117-125 of human synuclein, alpha
Protein A
Primary
6622
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