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CD163 Monoclonal Antibody (GHI/61), Biotin, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA517718

Additional Details : Weight : 0.01000kg

Product Code. 15334001

  • 3730.00 SEK / 100µg
Estimated Shipment: 27-05-2024
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Description

Description

MA5-17718 targets CD163/M130 in FACS, IHC (F), IP, and WB applications and shows reactivity with Human samples. The MA5-17718 immunogen is mouse monoclonal antibodies raised against human CD163.

CD163 (M130 antigen, Ber-Mac3, Ki-M8, SM4) is a 130 kDa membrane glycoprotein, a member of the scavenger receptor cysteine-rich superfamily, and a receptor for the hemoglobin-haptoglobin complex. CD163 protects tissues from free hemoglobin-mediated oxidative damage, and may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. CD163 is expressed exclusively on the cell surface of human monocytes and macrophages that evolve predominantly in the late phase of inflammation. Specifically, CD163 is present on all circulating monocytes and most tissue macrophages except those found in the mantle zone and germinal centers of lymphoid follicles, interdigitating reticulum cells and Langerhan's cells. CD163 is present on all CD14 positive monocytes, most CD64 positive monocytes, and shows higher expression on CD16 positive monocytes. CD163 is upregulated on mononuclear phagocytes by IL-10, IL-6 and dexamethasone. Lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) both induce shedding of CD163 from the cell surface into plasma or cell supernatant. CD163 binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner, and exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP1S phenotype. Further, CD163 also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.
Specifications

Specifications

CD163
Monoclonal
0.1 mg/mL
PBS with 4-5mg/mL BSA and 0.02% sodium azide
Q86VB7
CD163
Mouse monoclonal antibodies raised against human CD163.
100 μg
Primary
Human
Antibody
IgG1 κ
Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
GHI/61
Biotin
CD163
CD163; CD163 antigen; CD163 molecule; CD163v2; CD163v3; Hemoglobin scavenger receptor; M130; macrophage-associated antigen; MM130; putative CD163 antigen; SCARI1; Scavenger receptor cysteine-rich type 1 protein M130; sCD163; Soluble CD163; Soluble sCD163
Mouse
Protein G
RUO
9332
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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