missing translation for 'onlineSavingsMsg'
Learn More

CD20 Monoclonal Antibody (DFA-7), FITC, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA112054

Additional Details : Weight : 0.01000kg

Product Code. 11583523

This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.


Description

Description

CD20 is a non-glycosylated surface phosphoprotein that has a molecular weight range of 33-37 kDa depending on the degree of phosphorylation. CD20 is expressed on mature and most maligt B cells, in a subpopulation of T lymphocytes and follicular dendritic cells. CD20 expression on B cells is synchronous with the expression of surface IgM and it regulates transmembrane calcium conductance, cell cycle progression and B-cell proliferation. CD20 is also associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change, and/or BCR (B cell antigen receptor) aggregation. After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell maligcies, but does not become internalized or shed from the plasma membrane following monoclonal antibody treatment. Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.
Specifications

Specifications

CD20
Monoclonal
FITC
P11836
MS4A1
LB lymphoblastoid cell line
100 Tests
Primary
Human
Antibody
IgG1
Flow Cytometry
DFA-7
MS4A1
B1, Bp35, CD20, LEU-16, MGC3969, MS4A1
Mouse
Protein A/G
RUO
931
4° C, do not freeze
Liquid
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers