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CD31 Rat anti-Mouse, Clone: ER-MP12, Invitrogen™

Rat Monoclonal Antibody

Brand:  Invitrogen MA140074

Additional Details : CAS Number : 69-74-9 Weight : 0.01000kg

Product Code. 11529682

  • 3845.00 SEK / 100µg


Estimated Shipment
21-07-2020
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Description

Description

The mouse hematopoietic progenitor cell antigen is Platelet-Endothelial Cell Adhesion Molecule (PECAM)-1 (CD31) of 113 kDa. PECAM-1 is a member of the immunoglobulin superfamily.This heavily glycosylated protein is found in the entire vascular endothelium of adult mice, making it a commonly used endothelial marker, and functions in mediating cellular adhesion by heterophilic and homophilic mechanisms. The type I transmembrane protein is composed of an extracellular region of six Ig-like homology domains, a 19-residue transmembrane domain, and a 118 residue cytoplasmic tail and is differentially glycosylated involving N-linked and Olinked glycosylation sites. The signalling of PECAM-1 is based on 2 immuno receptor tyrosine inhibitory motifs (ITIMs) in its cytoplasmic domain. These ITIM domains can serve as docking sites for signalling molecules such as protein tyrosine phosphatases, and ligation of PECAM-1 can induce phosphorylation of tyrosine- and serine/threonineresidues of these intracellular regions eventually leading to activation of signalling pathways. The biological characteristics of PECAM-1 in these pathways and cellular adhesion have been mapped to specific regions of the PECAM-1 molecule. PECAM-1 is deteted within the lyphopoietic islands in the spleen of newborn (day 12) and the bone marrow of adult mice. Capillary endothelial cells of adult mice also express PECAM-1. Furthermore, it is expressed on most cells of the hematopoietic lineage including platelets, monocytes, neutrophils, and lymphocyte subsets. Besides adhesive properties PECAM-1 is an efficient signalling molecule. The protein is involved in vascular biology including angiogenesis, platelet function, and thrombosis, mechanosensing of endothelial cells, and regulation of multiple stages of leukocyte migration through venular walls.
Specifications

Specifications

CD31
Monoclonal
0.1 mg/mL
PBS with 0.1% BSA and 0.02% sodium azide
Q08481
CD31 antigen, CD31/EndoCAM, GPIIA′, PECA1, PECAM-1, CD31/EndoCAM, adhesion molecule, endoCAM, platelet endothelial cell adhesion molecule
Rat
IgG2a
100 μg
4° C
Primary
18613
ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
ER-MP12
Unconjugated
Pecam1
Liquid
PECAM1
Murine macrophage precursor hybrid W1C3cell hybrid
Protein G
RUO
Antibody
Monoclonal
Mouse
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