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ITGA4 Rat anti-Mouse, Biotin, Clone: R1-2, Invitrogen™

Rat Monoclonal Antibody

Brand:  Invitrogen MA517804

Additional Details : Weight : 0.01000kg

Product Code. 15334081

  • 1506.00 SEK / 100µg

Estimated Shipment: 01-10-2021

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Description

Description

The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta1, the gut mucosal homing receptor for peripheral T cells. At least two isoforms are known to exist.
Specifications

Specifications

ITGA4
Monoclonal
0.1 mg/mL
PBS with 4-5mg/mL BSA and 0.02% sodium azide
Q00651
269C wild type, CD49 antigen-like family member D, VLA-4 subunit alpha, antigen CD49D, alpha-4 subunit of VLA-4 receptor, ITGA4, ITGA-IV
Rat
IgG2b
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
16401
Flow Cytometry, Immunohistochemistry (Frozen)
R1-2
Biotin
Itga4
Liquid
ITGA4
Peyers Patch HEV binding lymphoma line (TK1)
Protein G
RUO
Antibody
Monoclonal
Mouse
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