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ICAM-1 Monoclonal Antibody (W-CAM-1), Invitrogen™
Beskrivning
MA5-13021 targets CD54 in WB, FACS, FN, IF, and IHC (F) applications and shows reactivity with Human samples. The MA5-13021 immunogen is raji Burkitt lymphoma cells.
ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.
Specifikationer
Specifikationer
| Antigen | ICAM-1 |
| Användningsområden | Flow Cytometry, Functional Assay, Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot |
| Klassificering | Monoclonal |
| Klona | W-CAM-1 |
| Koncentration | 0.2 mg/mL |
| Konjugera | Unconjugated |
| Formulering | PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4 |
| Gen | ICAM1 |
| Genaccessionsnr. | P05362 |
| Gene Alias | BB2; CD54; cell surface glycoprotein P3.58; Human rhinovirus receptor; ICAM; Icam1; ICAM-1; ICAM-1; CD54 homolog; Intercellular adhesion molecule 1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; intercellular adhesion molecule-1; intercellular adhesion molecule-1 precursor; Ly 47; Ly-47; major group rhinovirus receptor; MALA2; MALA-2; MyD10; P3.58; sCD54; soluble CD54; Surface antigen of activated B cells |
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Produkttitel
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