IL-22 Receptor alpha Rat anti-Mouse, Clone: 496514, Invitrogen™

Description

In direct ELISAs, 25% cross-reactivity with recombit human (rh) IL-22 R alpha 1 is observed and no cross-reactivity with rhIL-20 R alpha, recombit mouse (rm) IL-20 R alpha, rhIL-22BP, or rmIL-22BP is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.