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Phospho-CD28 (Tyr218) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA538446
Additional Details : Weight : 0.00900kg
Description
CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary’s Disease.Specifications
Phospho-CD28 (Tyr218) | |
Polyclonal | |
Unconjugated | |
CD28 | |
MGC138290, Tp44, CD28 antigen, T-cell-specific surface glycoprotein CD28 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
12487, 940 | |
-20°C | |
Liquid |
Western Blot | |
1 mg/mL | |
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
P10747, P31041 | |
CD28 | |
A synthetic phosphopeptide derived from human CD28 around the phosphorylation site of Tyr218 (A-A-YP-R-S) | |
100 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |