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Invitrogen™ Phospho-CHK1 (Ser345) Monoclonal Antibody (S.48.4)
Rabbit Monoclonal Antibody
Brand: Invitrogen™ MA515145
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Beskrivning
It is not recommended to aliquot this antibody.
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network. CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress. When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase. Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.
Specifikationer
| Phospho-CHK1 (Ser345) | |
| Monoclonal | |
| 37 μg/mL | |
| 0.01M HEPES with 50% glycerol, 0.15M NaCl, 100 μg/mL BSA and <0.02% sodium azide; pH 7.5 | |
| O14757, O35280, Q91ZN7 | |
| Chek1 | |
| Synthetic phosphopeptide corresponding to residues surrounding pSer345 of human Chk1. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat, Monkey | |
| Antibody | |
| IgG |
| Flow Cytometry, Western Blot, Immunocytochemistry | |
| S.48.4 | |
| Unconjugated | |
| Chek1 | |
| C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 1111, 12649, 140583 | |
| -20°C | |
| Liquid |
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