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Phospho-CD25 (Ser268) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA538609

Additional Details : Weight : 0.00900kg

Product Code. 15505531

  • 4195.00 SEK / 100µg
Estimated Shipment: 06-05-2024
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Description

Description

CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. The expression of IL2 in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. IL2 is primarily produced by mature T cells. IL2 plays an important role as a growth factor, differentiation factor, and regulator of cell death. IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Specifications

Specifications

Phospho-CD25 (Ser268)
Polyclonal
Unconjugated
IL2RA
IL2 RA antibody, Il2ra antibody, Interleukin 2 receptor alpha chain antibody, TAC antigen antibody, IL-2R alpha chain
Rabbit
Antigen affinity chromatography
RUO
16184, 3559
-20°C
Liquid
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
P01589, P01590
IL2RA
A synthetic phosphopeptide derived from human IL-2Ralpha/CD25 around the phosphorylation site of Ser268 (R-K-SP-R-R)
100 μg
Primary
Human, Mouse
Antibody
IgG
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