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Phospho-p27 Kip1 (Thr187) Monoclonal Antibody (2B10B7), Invitrogen™

Mouse Monoclonal Antibody

Brand: Invitrogen 379700

Product Code. 10067322

4450.00 SEK / Each

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For Research Use Only. All usage must comply with product instructions.

This item is not returnable. View return policy

Description

p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest. p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. p27 Kip1 has a molecular weight of approximately 27kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

Specifications

Antigen	Phospho-p27 Kip1 (Thr187)
Classification	Monoclonal
Concentration	0.5 mg/mL
Formulation	PBS with 0.1% sodium azide; pH 7.4
Gene Accession No.	P46527
Gene Symbols	Cdkn1b
Immunogen	Synthetic peptide encompassing the phosphorylated Thr187 residue of human p27
Quantity	100 μg
Primary or Secondary	Primary
Target Species	Human
Product Type	Antibody
Isotype	IgG1 κ

Applications	ELISA, Western Blot
Clone	2B10B7
Conjugate	Unconjugated
Gene	Cdkn1b
Gene Alias	AA408329; AI843786; Cdki1b; CDKN1B; CDKN4; CDN1B; cyclin dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor 1B (p27 Kip1); Cyclin-dependent kinase inhibitor 1B (p27, Kip1); cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor p27 Kip1; cyclin-dependent kinase inhibitor p27/Kip1; KIP1; MEN1B; MEN4; p27; P27 CDKN1B; p27(KIP1); p27Kip1
Host Species	Mouse
Purification Method	Affinity chromatography
Regulatory Status	RUO
Gene ID (Entrez)	1027
Content And Storage	-20°C
Form	Liquid

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Lot Number	Certificate Type	Date	Catalog Number
Lot Number3215908	Certificate TypeCertificate of Analysis	Date08/05/2025	Catalog Number

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Phospho-p27 Kip1 (Thr187) Monoclonal Antibody (2B10B7), Invitrogen™ > 100 μg; Unconjugated

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Phospho-p27 Kip1 (Thr187) Monoclonal Antibody (2B10B7), Invitrogen™

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