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Phospholamban Mouse anti-Canine, Chicken, Guinea Pig, Human, Mouse, Ovine, Porcine, Rabbit, Rat, Clone: 2D12, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA3922

Additional Details : Weight : 0.01000kg

Product Code. 11565802

  • 3500.00 SEK / 100µL


EU Stock 8
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Description

Description

Phospholamban (PLB) is a 52 amino acid phosphoprotein which regulates the calcium pump of cardiac sarcoplasmic reticulum (SR). PLB is an oligomer of five identical subunits each having a cytoplasmic and transmembrane domain. The cytoplasmic domain (residues 1-25) contains the phosphorylation sites and is highly basic and readily cleaved by proteases; whereas the transmembrane domain (residues 25-52) is mostly hydrophobic, protease resistant and stabilizes the pentamer. Following adrenergic stimulation of cardiac muscle, PLB is phosphorylated at Ser16 and at Thr17 which is correlated with stimulation of calcium transport activity across the SR membrane and relaxation of cardiac fibers

Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly

Specifications

Specifications

Phospholamban
Monoclonal
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
P61012, P26677, P26678, P61014, P61013, P61015, P61016
PLN; phospholamban; CMD1P; PLB; cardiac phospholamban; CMH18
Mouse
IgG2a
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
100009299, 100721387, 101102067, 18821, 396378, 397421, 414755, 5350, 64672
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
2D12
Unconjugated
PLN
Liquid
PLN
Synthetic peptide corresponding to residues D(2) K V Q Y L T R S A I R R A S T I E M P Q Q A R(25) of canine Phospholamban.
Protein A
RUO
Antibody
Monoclonal
Canine, Chicken, Guinea Pig, Human, Mouse, Ovine, Porcine, Rabbit, Rat
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