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Ras Mouse, Unlabeled, Clone: 18, BD

Mouse Monoclonal Antibody

3790.00 SEK - 6115.00 SEK

Specifications

Antigen Ras
Clone 18
Concentration 250μg/mL
Applications Western Blot
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
10074553
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BD Biosciences
610001
50 μg
3790.00 SEK
Each
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Estimated Shipment: 26-04-2024
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15825209
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BD Biosciences
610002
150 μg This item is currently unavailable or has been discontinued.
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Description

Description

Ras and related proteins of the Ras superfamily play critical roles in the control of normal and neoplastic proliferation. In mammalian cells there are four true Ras proteins (encoded by Ha- ras , N- ras , Ki- ras A, and Ki- ras B ) which, upon mutational activation, can function as independent oncogenes. These proteins relay signals from tyrosine kinases at the plasma membrane which subsequently lead to the nucleus via a network of serine/threonine kinases . The p21ras protein is active in its GTP-bound state. This form is slowly converted to the GDP-bound form by the intrinsic GTPase activity of Ras. This activity is greatly enhanced byGTPase-activating proteins (GAPs) which subsequently lead to removal of the GTP molecule and replacement with GDP. Maintenance of Ras in the GTP form can lead to transformation. One class of Ras mutations, commonly found in human tumors, results in an accumulation of Ras-GTP. The mutant Ras can bind GAP, but GAP bound in this manner seems unable to affect the Ras-GTPase activity.
Specifications

Specifications

Ras
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1 κ
Affinity Purified
18
Western Blot
Unconjugated
RUO
Canine, Chicken, Human, Mouse, Rat
Human Ras (Ha-ras) aa. 1-190
Primary
Store undiluted at -20°C.
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