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SMAD6 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA124467

Additional Details : Weight : 0.01000kg

Product Code. 11571033

  • 4390.00 SEK / 100µg
Estimated Shipment: 16-04-2024
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Description

Description

PA1-24467 detects Smad6 in Human samples. PA1-24467 has been successfully used in Western Blot and immunohistochemistry (paraffin) procedures. PA1-24467 immunogen corresponds to Polyclonal antibody from rabbits immunized with a synthetic peptide region of human MADH6. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
Specifications

Specifications

SMAD6
Polyclonal
Unconjugated
O43541
SMAD6
Synthetic peptide region of human MADH6.
100 μg
Primary
Human
Antibody
IgG
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
SMAD6
HsT17432, MADH6, MADH7
Rabbit
IgG fraction
RUO
4091
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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