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SMAD6 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA124467
Additional Details : Weight : 0.01000kg
Description
PA1-24467 detects Smad6 in Human samples. PA1-24467 has been successfully used in Western Blot and immunohistochemistry (paraffin) procedures. PA1-24467 immunogen corresponds to Polyclonal antibody from rabbits immunized with a synthetic peptide region of human MADH6. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.Specifications
SMAD6 | |
Polyclonal | |
Unconjugated | |
O43541 | |
SMAD6 | |
Synthetic peptide region of human MADH6. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG |
Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
SMAD6 | |
HsT17432, MADH6, MADH7 | |
Rabbit | |
IgG fraction | |
RUO | |
4091 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |