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Synaptotagmin 1 Polyclonal Antibody, Invitrogen™
Sheep Polyclonal Antibody
Brand: Invitrogen OSS00065G
Additional Details : Weight : 0.99000kg
Description
Glycerol (1:1) may be added for additional stability. Reconstitute in 500 uL of sterile water.
Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release. Studies indicate that synaptotagmin’s Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane. It has been demonstrated that discrete residues within the c(2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size. Synaptotagmin 1 may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Further, Synaptotagmin 1 binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has been reported. Synaptotagmin 1 can also bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Diseases associated with the dysfunction of Synaptotagmin 1 include food-borne botulism and infant botulism.Specifications
Synaptotagmin 1 | |
Polyclonal | |
Unconjugated | |
P46096, P21707 | |
SYT1 | |
A synthetic peptide from rat, mouse Synaptotagmin-1 | |
500 μg | |
Primary | |
Mouse, Rat | |
Antibody | |
IgG |
Immunohistochemistry, Western Blot | |
1 mg/mL | |
Syt1 | |
Synaptotagmin-1, Synaptotagmin I, SytI, p65, SVP65 | |
Sheep | |
Ammonium sulfate precipitation | |
RUO | |
20979, 25716 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Lyophilized |