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ARAP2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 25143-1-AP-20UL
Additional Details : Weight : 0.00010kg
Description
ARAP2 also known as Centaurin-delta-1 is a protein with ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. A phosphatidylinositol-3, 4, 5-trisphosphate-dependent GTPase-activating protein, ARAP2, binds to RhoA-GTP, but lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. It modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Usually ARAP2 is activated by phosphatidylinositol-3, 4, 5-trisphosphate (PtdIns(3, 4, 5)P3) binding and can be activated by phosphatidylinositol-3, 4-bisphosphate (PtdIns(3, 4, 5)P2) binding, albeit with lower efficiency. ARAP2 associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. It is usually detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. .Specifications
ARAP2 | |
Polyclonal | |
Unconjugated | |
ARAP2 | |
ARAP2, Centaurin delta 1, CENTD1, Cnt d1, KIAA0580, PARX, Protein PARX | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
116984, 212285, 305367 | |
-20°C | |
Liquid |
Western Blot, Immunoprecipitation | |
0.43 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
Q8BZ05, Q8WZ64 | |
Arap2 | |
ARAP2 Fusion Protein Ag18469 | |
20 μL | |
Primary | |
Mouse, Rat, Human | |
Antibody | |
IgG |