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Tocris Bioscience™ AS 1949490
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Produktkod. 18793999
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25 mg
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Produktkod. Kvantitet
18793999 25 mg
18777956 5 mg
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Produktkod. 18793999 Leverantör Tocris Bioscience™ Leverantörsnummer 3718/25

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Beskrivning

SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) inhibitor

AS 1949490 is a selective SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2) inhibitor (IC50 values are 0.34 μM and 0.62 μM for mouse and human respectively); displays approximately 30-fold affinity for SHIP2 over SHIP1. Increases insulin-induced phosphorylation of Akt in L6 myotubules. Stimulates activation of glucose metabolism; regulates gluconeogenesis in vitro and in vivo and exhibits antidiabetic effects. Also promotes increased BDNF mRNA levels in cultured cortical neurons and has memory enhancing and antidepressant effects in vivo.
TRUSTED_SUSTAINABILITY

Specifikationer

Kemiskt namn eller material 3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide
CAS 1203680-76-5
Analysprocentintervall >99%
Kvantitet 25 mg
Molekylformel C20H18ClNO2S
Formel vikt Observed MW: 371.88
Produkttitel
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