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Tocris™ ASB 14780

Potent and selective cytosolic phospholipase A2 alpha (cPLA2α) inhibitor; active in vivo; orally bioavailable

Brand:  Tocris™ 6316/5

Product Code. 18748016

  • 1910.00 SEK / 5mg

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Description

Description

ASB 14780 is a potent and selective cytosolic phospholipase A2 alpha (cPLA2α) inhibitor (IC50 = 20 nM). Selective for cPLA2α over secreted PLA2α (sPLA2α; exhibits no inhibition at 10 μM). Inhibits cPLA2α-dependent inflammatory responses in vitro in guinea pig and human whole-blood assays. Improves diet-induced liver injury and CCl4-induced hepatic fibrosis in vivo. Orally bioavailable.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

3-(3-Phenethyl-1-(4-phenoxyphenyl)-1 H-indol-5-yl)propanoic acid tris salt
5 mg
C31H27NO3.C4H11NO3
1069046-00-9
Phospholipase Inhibitors
0.98
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