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Invitrogen™ ASK1 Recombinant Rabbit Monoclonal Antibody (SU36-06)
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA542430
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Beskrivning
Positive Control: 293 cell lysates, A549, Hela, MCF-7, human lung carcinoma tissue, human pancreas tissue, mouse pancreas tissue, human breastcarcinoma tissue. Subcellular Location: Endoplasmic reticulum, Cytoplasm.
MAP3K5 (ASK1) is a serine/threonine kinase that is abundantly expressed in human heart and pancreas and are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activates c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death and a catalytically inactive form of ASK1 inhibited TNF-a-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.
Specifikationer
| ASK1 | |
| Recombinant Monoclonal | |
| 1 mg/mL | |
| TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4 | |
| O35099, Q99683 | |
| MAP3K5 | |
| Synthetic peptide within N-terminal human ASK1. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
| Immunohistochemistry (Paraffin), Western Blot, Immunohistochemistry (Paraffin), Western Blot | |
| SU36-06 | |
| Unconjugated | |
| MAP3K5 | |
| 7420452D20Rik; apoptosis signal regulating kinase 1; apoptosis signal-regulating kinase 1; ASK; ASK 1; ASK1; ASK-1; EC 2.7.11.25; kinase ASK1; M3K5; MAP/ERK kinase kinase 5; Map3k5; MAPK/ERK kinase kinase 5; MAPKKK5; MEK kinase 5; MEKK 5; Mekk5; mitogen activated protein kinase kinase kinase 5; mitogen-activated protein kinase kinase kinase 5; RGD1306565; RP3-325F22.4 | |
| Rabbit | |
| Protein A | |
| RUO | |
| 26408, 4217 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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