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Tocris Bioscience™ Astemizole

Produktkod. 18792664
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Kvantitet:
50 mg
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18792664 50 mg
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Product Code. 18792664 Supplier Tocris Bioscience™ Supplier No. 3489/50

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Description

Orally active, potent H1 antagonist. Also KV11.1 (hERG) channel blocker

Orally active, potent histamine H1 antagonist (IC50 = 4 nM) that displays 20-fold, > 250-fold and > 250-fold selectivity over 5-HT, dopamine and muscarinic acetylcholine receptors respectively. Exhibits antimalarial activity in multidrug resistant strains in vitro (IC50 = 227 - 734 nM). Also potent KV11.1 (hERG) channel blocker (IC50 = 0.9 nM) that displays cardiotoxicity in vivo.
TRUSTED_SUSTAINABILITY

Specifications

Kemiskt namn eller material Astemizole
CAS 68844-77-9
Kvantitet 50 mg
Molekylformel C28H31FN4O
Formel vikt 458.57
Renhet >99%
Molekylvikt (g/mol) 458.581
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