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Tocris Bioscience™ Asunaprevir
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Produktkod. 18758066
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50 mg
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Produktkod. Kvantitet
18758066 10 mg
18737856 50 mg
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Produktkod. 18758066 Leverantör Tocris Bioscience™ Leverantörsnummer 7755/10

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Beskrivning

Potent hepatitis C virus (HCV) NS3 protease inihibitor

Asunaprevir is a potent HCV NS3 protease inhibitor (IC50 = 0.2-3.5 nM). Asunaprevir can be used to control CRIPSR-Cas9 gene editing via the small molecule-assisted shut-off (SMASh) technique, which involves fusion of Cas9 to a peptide comprising a protease domain and a degron tag. Asuprenavir blocks the protease-mediated removal of the degron tag leading to degradation of Cas9 through proteasome and autophagolysosome pathways. It can also be used as a resversible switch to control CAR (chimeric antigen receptor)-T cells, where the CAR has been modified by insertion of a hepatitis C virus nonstructural protein 3 protease (HCV-NS3) between the scFv and the hinge domains. Also inhibits SARS-CoV-2 Mpro activity (IC50 = 15-48.4 μM).
TRUSTED_SUSTAINABILITY

Specifikationer

Kemiskt namn eller material 1-[[N-tert-Butoxycarbonyl-L-tert-leucyl-trans-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-L-prolyl]amino]-N-(cyclopropylsulfonyl)-(1 R,2 S)-2-vinylcyclopropane-1-carboxamide
CAS 630420-16-5
Kvantitet 10 mg
Mål CRISPR Reagents
Molekylformel C35H46ClN5O9S
Renhet 0.98
Produkttitel
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