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Eurofins DiscoverX ATR/ATRIP Protein, Active
Beskrivning
Serine/threonine-protein kinase ATR activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. ATR interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage.
GenBank NM_001184.3* / GenBank AF451323.1 * Note: the recombinant ATR contains the amino acid substitution M211T with reference toGenBank NM_001184.3. M211T is reported inGenBank XM_001131387.1.
Specifikationer
Specifikationer
| Formulering | mg/mL of enzyme in storage buffer. |
| Molekylvikt (g/mol) | 303 kDa (ATR) and 87 kDa (ATRIP) |
| Kvantitet | 10 μg |
| Art | Human |
| Rekombinant | Recombinant |
| Protein Tag | ATR-FLAG-tag / ATRIP-cMyc-tag |
| Uttryckssystem | Recombinant enzyme expressed in mammalian cells |
| Proteinform | Full-length |
| Renhet eller kvalitetsklass | Combined ≥43% ration 1:1 to 2:1 ATR:ATRIP |
| Protein | ATR/ATRIP, active |
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