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Invitrogen™ Bax Polyclonal Antibody
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Produktkod. 17138873
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100 μL
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Produktkod. Kvantitet
17138873 100 μL
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Produktkod. 17138873 Leverantör Invitrogen™ Leverantörsnummer PA5110949

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Beskrivning

Rabbit Polyclonal Antibody

Immunogen sequence: GPTSSEQIMK TGALLLQGFI QDRAGRMGGE APELALDPVP QDASTKKLSE CLKRIGDELD SNMELQRMIA AVDTDSPREV FFRVAADMFS DGNFNW Highest antigen sequence indentity to the following orthologs: Rat - 88%, Mouse - 90%.

BAX is a members of the Bcl-2 Family and plays an important role in regulation of apoptosis. Whereas Bcl-2 is commonly regarded as an anti-apoptotic protein, BAX is considered to have a pro-apoptotic function. Regulation of apoptosis is supposed to involve both homo- and heterodimerization of different isoforms of BAX and Bcl-2. The Bax gene encodes different isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa), whereas both isoforms contain the BH1, BH2 and BH3 domains, Bax beta has a unique carboxyl terminus and does not contain a hydrophobic transmembrane domain. Bcl-2 is also expressed in different Isoforms. Bcl-2 beta differs in the 3' UTR and coding region compared to variant alpha. Bcl-2 beta is shorter (22 kDa) and has a distinct C-terminus compared to Bcl-2 alpha (26 kDa). BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.
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Specifikationer

Antigen Bax
Användningsområden Immunohistochemistry (Paraffin), Western Blot
Klassificering Polyclonal
Koncentration 0.1 mg/mL
Konjugera Unconjugated
Formulering PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gen BAX
Genaccessionsnr. Q07812
Gene Alias apoptosis regulator BAX; Apoptosis regulator Bcl-X; Bax; Bax zeta; BAX-ALPHA; Bax-alpha protein; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; BCL2 associated X protein; BCL2 associated X, apoptosis regulator; BCL2 like 1; BCL2-associated protein; Bcl-2-associated protein Bax; Bcl2-associated protein Bax; Bcl-2-associated X protein; BCL2-associated X protein; BCL2-associated X protein omega; BCL2L; BCL2L1; Bcl2-L-1; BCL2L4; Bcl2-L-4; BCL2-like 1; bcl-2-like protein 1; Bcl-2-like protein 4; BCLX; Bcl-X; BCL-XL/S; PPP1R52; protein phosphatase 1, regulatory subunit 52
Gensymboler BAX
Värd art Rabbit
Immunogen Recombinant Protein corresonding to Human Bax. Recombinant protein control fragment (Product #RP-95261).
Reningsmetod Antigen affinity chromatography
Kvantitet 100 μL
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 581
Målarter Human
Innehåll och lagring Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Produkttyp Antibody
Form Liquid
Isotyp IgG
Visa mer Visa mindre
Produkttitel
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