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BCL6, clone: GI191E, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9887-80

Additional Details : Weight : 0.01000kg

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Product Code. 15248207

  • 928.00 SEK / 25µg


Estimated Shipment date
from Supplier 25-09-2018
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Description

Description

Description: This GI191E monoclonal antibody reacts with mouse and human Bcl-6, which is also known as B-cell lymphoma 6. A member of the POZ family of transcriptional repressors, Bcl-6 is expressed most abundantly in germinal center B cells, as well as in differentiating and activated B cells. This 79-kDa protein is essential for germinal center B cell proliferation and survival. Moreover, during B cell development, Bcl-6 plays an important role in promoting pre-B cell survival to enable the generation of a diverse B cell repertoire. Moreover, Bcl-6 is expressed constitutively in diffuse large B cell lymphomas (DLBCLs), Burkitt's lymphoma, and non-Hodgkin's lymphoma. Reports also suggest expression of Bcl-6 in CD4+ T follicular helper cells and memory T cells. Bcl-6 has been reported to be antagonized by Blimp-1.Applications Reported: This GI191E antibody has been reported for use in immunoblotting (WB) and immunohistochemistry (FFPE).Applications Tested: This GI191E antibody has been tested by immunoblotting of reduced cell lysate prepared from A20 cells and by immunohistochemistry on human tissue using high pH antigen retrieval. This antibody can be used at less than or equal to 5 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

BCL6
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
P41182, P41183
B-cell lymphoma 6 protein, BCL-6, Zinc finger protein 51, LAZ-3 protein, BCL-5, Zinc finger and BTB domain-containing protein 27, ZNF51, ZBTB27, LAZ3, BCL5, BCL6
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
HumanþMurine
Immunohistochemistry (Paraffin)þWestern Blot
GI191E
Unconjugated
BCL6
Liquid
Bcl6
IgG1, kappa, kappa
25μg
Store at 2-8°C.
Primary
12053, 604
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