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Invitrogen™ Bcr Polyclonal Antibody
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Produktkod. 16643755
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Kvantitet:
100 μL
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Produktkod. Kvantitet
16643755 100 μL
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Produktkod. 16643755 Leverantör Invitrogen™ Leverantörsnummer PA599505

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Beskrivning

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Bcr.

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen Bcr
Användningsområden Western Blot, Immunocytochemistry
Klassificering Polyclonal
Koncentration 1 mg/mL
Konjugera Unconjugated
Formulering PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gen Bcr
Genaccessionsnr. P11274, Q6PAJ1
Gene Alias 5133400C09Rik; ABL; AI561783; AI853148; ALL; BCR; BCR activator of RhoGEF and GTPase; BCR protein; BCR, RhoGEF and GTPase activating protein; bcr/abl; BCR/FGFR1 chimera protein; BCR1; breakpoint cluster region; breakpoint cluster region homolog; breakpoint cluster region protein; c-ABL; c-abl oncogene 1; CML; D22S11; D22S662; EC 2.7.11.1; FGFR1/BCR chimera protein; JTK7; Kiaa3017; mKIAA3017; p150; PHL; renal carcinoma antigen NY-REN-26; RP11-83J21.1; v-abl
Gensymboler Bcr
Värd art Rabbit
Immunogen A synthesized peptide derived from human BCR(Accession P11274), corresponding to amino acid residues V151-S201.
Reningsmetod Affinity Chromatography
Kvantitet 100 μL
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 110279, 613
Målarter Human, Mouse
Innehåll och lagring -20°C
Produkttyp Antibody
Form Liquid
Isotyp IgG
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