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  6. Bestatin, Thermo Scientific Chemicals

Bestatin, Thermo Scientific Chemicals

Catalog Number p-7042030
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Quantity:
100 mg
250 mg
58970-76-6
C16H24N2O4
308.38
MFCD00083262
VGGGPCQERPFHOB-MCIONIFRSA-N
bestatin, ubenimex, ubenimexum latin, ubenimex inn:jan, bestatin;ubenimex, s-2-2s,3r-3-amino-2-hydroxy-4-phenylbutanamido-4-methylpentanoic acid, ubenimex bestatin, chembl29292, 2s,3r-3-amino-2-hydroxy-4-phenylbutanoyl-l-leucine, 3-r-amino-2-s-hydroxy-4-phenylbutanoyl-s-leucine
72172
(2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid
CC(C)C[C@@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(O)=O
58970-76-6
C16H24N2O4
308.38
MFCD00083262
VGGGPCQERPFHOB-MCIONIFRSA-N
bestatin, ubenimex, ubenimexum latin, ubenimex inn:jan, bestatin;ubenimex, s-2-2s,3r-3-amino-2-hydroxy-4-phenylbutanamido-4-methylpentanoic acid, ubenimex bestatin, chembl29292, 2s,3r-3-amino-2-hydroxy-4-phenylbutanoyl-l-leucine, 3-r-amino-2-s-hydroxy-4-phenylbutanoyl-s-leucine
72172
(2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid
CC(C)C[C@@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(O)=O

Description

Bestatin can indirectly act on monocytes by inhibiting Aminopeptidase B, which in turn inhibits the catabolism of tuftsin. Bestatin has also been shown to inhibit Leukotriene A4 hydrolase. It can directly stimulate lymphocytes through its fixation on the cell surface. The agent has been used in multiple leukemia studies. Bestatin is an aminopeptidase inhibitor, inhibits enkephalin metabolism and leukotriene A4 hydrolase. Inhibits tumor cell proliferation.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Bestatin can indirectly act on monocytes by inhibiting Aminopeptidase B, which in turn inhibits the catabolism of tuftsin. Bestatin has also been shown to inhibit Leukotriene A4 hydrolase. It can directly stimulate lymphocytes through its fixation on the cell surface. The agent has been used in multiple leukemia studies. Bestatin is an aminopeptidase inhibitor, inhibits enkephalin metabolism and leukotriene A4 hydrolase. Inhibits tumor cell proliferation.

Solubility
Soluble in water (<1 25), DMSO (2 mg/ml), methanol (5 mg/ml), 1eq. NaOH (50 mM), ethanol (<1mg/mL at 25°C), acetic acid, aq. HCl, and alkaline solution. Insoluble in ethyl acetate, benzene, hexane, and chloroform.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
TRUSTED_SUSTAINABILITY
Melting Point 233°C to 236°C
Color White
Quantity 100 mg
Merck Index 14,9842
Solubility Information Soluble in water (<1 25),DMSO (2mg/ml),methanol (5mg/ml),1eq. NaOH (50 mM),ethanol (<1mg/ml at 25°C),acetic acid,aq. HCl,and alkaline solution. Insoluble in ethyl acetate,benzene,hexane,and chloroform.
Formula Weight 308.37
Physical Form Powder
Chemical Name or Material Bestatin

RUO – Research Use Only

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