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Invitrogen™ beta Dystroglycan Polyclonal Antibody
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Produktkod. 11377673
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Kvantitet:
100 μg
Förpackningsstorlek:
100µg
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11377673 100 μg 100µg
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Produktkod. 11377673 Leverantör Invitrogen™ Leverantörsnummer PA519731

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Beskrivning

Rabbit Polyclonal Antibody

This antibody is predicted to react with mouse, rabbit, cow and dog based on sequence homology.

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen beta Dystroglycan
Användningsområden Western Blot
Klassificering Polyclonal
Koncentration 0.9 mg/mL
Konjugera Unconjugated
Formulering PBS with 1% BSA and 0.02% sodium azide; pH 7.4
Gen DAG1
Genaccessionsnr. Q14118
Gene Alias 156DAG; A3a; AGRNR; Alpha-DG; Alpha-dystroglycan; Beta-DG; Beta-dystroglycan; D9Wsu13e; DAG; DAG1; Dag-1; DG; Dp427; Dp71; dystroglycan; dystroglycan 1; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystrophin associated glycoprotein 1; Dystrophin-associated glycoprotein 1; MDDGA9; MDDGC7; MDDGC9
Gensymboler DAG1
Värd art Rabbit
Immunogen Synthetic peptide conjugated to KLH derived from within residues 650 - 750 of Human Dystroglycan precursor.
Reningsmetod Antigen Affinity Chromatography
Kvantitet 100 μg
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 1605
Målarter Human
Innehåll och lagring -20°C or -80°C if preferred
Produkttyp Antibody
Form Liquid
Isotyp IgG
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Produkttitel
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