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ACROBiosystems Biotinylated Human Alpha-Synuclein Protein, His, Avitag

Brand:  ACROBiosystems ALN-H82H8-25ug

Additional Details : Weight : 0.00010kg

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Product Code. 17216050

  • 4694.50 SEK / 25µg
Estimated Shipment: 16-06-2023
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Description

Description

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 18.0 kDa. The protein migrates as 23 kDa under reducing (R) condition (SDS-PAGE).
Specifications

Specifications

NP_000336.1
>95% as determined by SDS-PAGE.
Biotinylated Human Alpha-Synuclein, His,Avitag (ALN-H82H8) is expressed from E.coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1).
-20°C
Alpha-Synuclein
His Tag & Avi Tag
Less than 1.0 EU / µg by the LAL method.
Powder
Human
18.0 kDa
25 µg
Met 1 - Ala 140
SNCA,NACP,PARK1,alpha-Synuclein
Precision Avi
100 mM NaAC, pH7.0
E.coli
MABSol™ Biotin Labeled Proteins
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