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ACROBiosystems Biotinylated Human Alpha-Synuclein Protein, His, Avitag
Brand: ACROBiosystems ALN-H82H8-25ug
Additional Details : Weight : 0.00010kg
Description
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 18.0 kDa. The protein migrates as 23 kDa under reducing (R) condition (SDS-PAGE).Specifications
| NP_000336.1 | |
| 25 μg | |
| Met 1 - Ala 140 | |
| SNCA,NACP,PARK1,alpha-Synuclein | |
| Precision Avi | |
| His Tag & Avi Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE. |
| 18.0 kDa | |
| Biotinylated Human Alpha-Synuclein, His,Avitag (ALN-H82H8) is expressed from E.coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1). | |
| -20°C | |
| Alpha-Synuclein | |
| Human | |
| 100 mM NaAC, pH7.0 | |
| E.coli | |
| MABSol™ Biotin Labeled Proteins |